Neurobiology of Disease A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance
نویسندگان
چکیده
Zhi-Ye Zhuang,1* Yeong-Ray Wen,1,2* De-Ren Zhang,1 Tiziana Borsello,3 Christophe Bonny,3,4 Gary R. Strichartz,1 Isabelle Decosterd,3,5 and Ru-Rong Ji1 1Department of Anesthesiology, Pain Research Center, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, 2Department of Anesthesiology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 110, Taiwan, 3Department of Cell Biology and Morphology, Faculty of Biology and Medicine, Lausanne University, CH-1005 Lausanne, Switzerland, 4Unit of Medical Genetics, Lausanne University, CH-1003, Lausanne, Switzerland, and 5Department of Anesthesiology, Anesthesiology Pain Research Group, Lausanne University Hospital, CH-1011 Lausanne, Switzerland
منابع مشابه
Role of nitric oxide and Jun N-terminal kinase in the development of dark neurons in the dorsal horn of the spinal cord following induction of inflammatory pain
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